Pedersen Lab
LABORATORY OF MicroRNA Biology and Blood Brain Barrier
Principal Investigator: Irene Pedersen
Pedersen Lab Home
RESEARCH
The research interest of the Irene Munk Pedersen (IMP) laboratory is based on the recent discovery of microRNAs (miRs), which has revolutionized our understanding of gene control. miRs play key roles in controlling development, stem cell fates and differentiation, and mutations in human miR genes have been linked to human disease.
The main focus of the lab is to investigate novel roles of specific miRs (identified using anti-miR library screens approaches) in cells and explore how to use RNA molecules (miRs and mRNAs) as tools to regulate/counteract potential disregulation in cancer (Research Program 1) and neurological disorders (Research Program 2). A separate line of research interest is to evaluate miRs function as restriction factors of mobile elements and retrovirus (LINE-1, hERVs and HIV-1) in human cells (Research Program 3).
FUNDING
NINDS
Research 1
miRs role in tumor niche interactions
Research 2
Repair of damaged BBB using miRs
Research 3
miRs as restriction factors controlling mobile elements and retrovirus
