Principal Investigator

Prior to joining Scintillon, Dr. Joel N. Buxbaum was Professor of Medicine at NYU School of Medicine and Professor of Molecular Medicine at The Scripps Research Institute where he was head of arthritis research and the W.M. Keck autoimmune disease center.  In recognition of his research contributions he was elected to the American Society for Clinical Investigation and the Association of American Physicians and received the Dart Biotechnology Award from NYU Medical School in 2013. He has served on many study sections and review groups including the Advisory council of the National Genome Research Institute of the NIH and chaired the council on clinical and research investigations of the American Cancer Society.  He is currently a member of the editorial boards of Amyloid and the FASEB journal and has served as a consultant to companies developing therapies for the systemic amyloidoses.

His major research interests focus on the genetics, pathogenesis and treatment of human protein misfolding diseases, many of which are age related, and include those that involve the central nervous system, such as Alzheimer’s and Parkinson’s diseases, and those with predominant systemic manifestations best exemplified by immunoglobulin L-chain and transthyretin amyloidosis, both of which affect the kidneys, heart and peripheral nervous systems.  His most recent work has examined the structural and functional relationships among amyloidogenic proteins and their possible roles in normal physiology including effects on the formation of microbial biofilms which are responsible for the persistence of infection on the surfaces of implanted prosthetic devices.

Joel buxbaumn, MD