Electrophysiology Burnham

Electrophysiology Core at the Sanford-Burnham Medical Research Institute

The Electrophysiology Core in Sanford-Burnham Medical Research Institute is a part of Neuroscience Center Core facility.  Together with its sibling facility in Salk Institute, run by Dr. Stephen F. Heinemann, the core will provide services for projects using electrophysiological approaches.


Administration and Operation

Dr. Zhang will oversee the Core facilities and ensure that the equipment is used appropriately. All projects will be subjected to approval and accommodated in the order they arise. A staff scientist will conduct experiments for accepted projects and for training.



The Electrophysiology Core provides access to a slice and a patch-clamp rig for electrophysiological recordings from brain slices and cell cultures, respectively. In addition, the Core is equipped with an oocyte recording rig.



To compliment our sibling facility in Salk institute, we will mainly provide services for experiments using cell cultures and oocytes.  These systems are best for studying drug/reagent interaction with receptors, native or recombinant, expressed in cell surfaces. The Core will assist each project with the experimental design, data collection and data interpretation. We will also train qualified personnel for conducting experiments themselves. We will accommodate projects using slice recordings if our sibling facility is not available at the time. Examples of services are listed below:

1).Patch-clamp recording from single cells include primary neuronal cultures or cell lines

2).Voltage-clamp recording from oocytes expressing recombinant receptors

3).Extracellular or patch-clamp recording from Brain Slices


Service charges

1)      Project performed by core personnel: $60/hour. 

2)      Training fee: $100/hour.

3)      Project performed by non-core personnel: $30/hour.  


Contact information

            Dongxian Zhang, Ph.D.

            Sanford-Burnham Medical Research Institute

            Building7, Rm 7203

            10901N. Torrey Pines Road

            La Jolla, CA 92037

            E-mail: dzhang@burnham.org
Phone: 858-795-5263